The term epidermolysis bullosa describes a group of rare genetic mechanicobullous disorders. The disease has several modes of inheritance with various degrees of severity and expression. A patient with simplex epidermolysis bullosa had typical cutaneous lesions and dental involvement. The teeth were severely affected by hypoplasia. Dental therapy consisted of placement of amalgam restorations and topical applications of fluoride. The need for, and advantages of, early preventive and restorative dental care are illustrated by the case presente