Purpose: The purpose of this in vitro study was to evaluate wear and fracture strength of chairside-milled new ceramic resins after artificial aging in a chewing simulator. Materials and Methods: Two ceramic resins (Lava Ultimate and Vita Enamic) and two conventional ceramics (IPS Empress CAD and Celtra Duo) were tested. For analysis of wear, baseline and follow-up scans of the specimens were made, the scans were superimposed, and the wear was calculated. To determine fracture strength, the specimens were loaded until they fractured. Results: Lava Ultimate showed the highest wear, caused the lowest wear of the opposing dentition, and showed statistically significantly higher fracture strength than conventional ceramics after cyclic loading. Conclusion: New ceramic resins for chairside milling are a good alternative to conventional ceramics.