The aim of present study was to evaluate the efficacy of demineralized freeze-dried bone allograft (DFDBA) alone and in combination with chorion membrane (CM) in the treatment of Grade II furcation defects using cone beam computed tomography (CBCT). Sites were randomly assigned to Group I (DFDBA) and Group II (DFDBA + CM). Probing pocket depth (PPD), clinical attachment level (CAL), gingival recession (GR), and horizontal probing depth (HPD) were evaluated at 3 and 6 months and defect volume at 6 months. DFDBA + CM led to significant improvement in all parameters, indicating additional benefits of combination therapy.