When associated with anterior open bite, Class II malocclusions have proven to be a daunting challenge for orthodontists. Aligner systems now seem to be able to treat various types of malocclusions, and in recent years, many studies have demonstrated their efficacy in correcting crowding, misalignment and diastemas, and even complex cases involving open bite and poor occlusal relationships. The present case report describes the management of Class II malocclusion and open bite in a growing patient using the Invisalign Teen system (Align Technology, San Jose, CA, USA). A specific protocol was followed during treatment planning: transverse expansion, control of the vertical dimension, and sagittal correction using Class II elastics. Clear aligners proved to be highly effective in the resolution of Class II malocclusion and open bite, inducing molar intrusion and mandibular repositioning.