Purpose: The successful osseointegration around immediate implants requires high

quality and quantity of osteogenesis around them. The role of magnesium as a boneenhancing

mineral, and as an adjunctive analgesic has been well documented in

orthopedic literature. However, there is a paucity of literature in its role in successful

osseointegration around immediate implants. This randomized controlled trial sought to

assess the promising impact of magnesium on osseointegration by examining various

aspects of implant stability, correlating them with serum bone markers, and establishing

a foundation for future research on its potential as a potent analgesic. Materials and

Methods: Immediate implant placement was done after the extraction of the indicated

mandibular molar tooth, and all the patients were segregated into 2 groups (Placebo-

Lactose, and Magnesium citrate). Bone regenerate in the peri-implant area was assessed

radiographically immediate post-operatively, on the 6th week and 12 weeks. Implant

stability was measured immediate post-operatively, at the 4th week and 12th week.

Serum parameters were procured pre-operatively and post-operatively for serum

calcium, serum alkaline phosphatase (ALP), and serum parathyroid hormone at the 8th

week, and serum vitamin D3 levels preoperatively. Results: 54 immediate implants

placed showed the demographics and baseline serum, clinical, and radiographic

parameters were comparable in both groups. Analysis of Implant Stability Quotient at

12th week showed statistically significant difference in intervention group both on

intergroup and intragroup analysis. Radiodensity measurement showed a statistically

significant difference in both intragroup and intergroup analysis in the intervention

group at the 6th and 12th week. In bone gap analysis, the difference in mean change in

the horizontal bone gap (HG) at 6 weeks was non-significant while the difference in

HG at the 12th week was significant in the intervention group. On intragroup analysis,

mean change HG at 6 weeks and 12 weeks both were significant only in intervention

group. Intergroup analysis of vertical bone gap (VG) 12 and VG 12-0 (mean difference

in the vertical bone gap from 12th week-day 0) showed a statistically significant

difference in the intervention group. On intragroup analysis, VG 12 was significantly

better in the intervention group. On serum analysis, ALP post-operatively was found to

be significantly raised (P=0.013) in intervention group. Numerical rating Scale (NRS)

analysis showed a significant decrease in post-op day 5 and 7, (P=0.017) and (P=0.002)

respectively. Conclusion: The oral magnesium citrate supplementation after immediate

implant placement helps in enhancing the stability of the immediate implants, along

with improved radiodensity around them which was found to be statistically significant.

It also helps in reducing the horizontal, and vertical gap around the implant and has

significant analgesic potential.