To assess the resistance to fracture of ceramic inlays, extracted sound human molars were restored with different ceramic materials and glass-ionomer or composite resin luting cement. Compression forces were applied to the specimens until they fractured, and maximal force developed, extent and location of fractures, and the micromorphology of the fractured surfaces were studied. Inlays made of Vitadur N with aluminum oxide profile and bonded with composite resin demonstrated the highest resistance among the restorative combinations, but their resistance was still lower than that of intact (control) teeth. The extent of fracture increased proportionally to the fracture resistance of the specimens. Scanning electron microscopic observation confirmed the effectiveness of the adhesion between composite resin and etched ceramic and the absence of sufficient micromechanical anchoring between glass-ionomer cement and etched ceramic.