Objective: The objective of the present study was to clinically evaluate the hybrid materials Vitremer and Dyract when used as pit and fissure sealants. Method and materials: The materials were applied in pairs on the mandibular permanent first molars of 100 children, 7 to 8 years old. Results: After 12 months of sealing, the clinical evaluation presented rates of 95.9% and 85.7% of complete retention for Dyract and Vitremer, respectively, indicating a statistically significant difference. The hybrid materials presented a statistically significant protective effect against caries compared with the control group at 6 and 12 months. Conclusion: The hybrid materials were able to control occlusal caries.