A young patient with dentinogenesis imperfecta and a dentition severely compromised by discolorations, abrasion, and breakage of enamel on several teeth was prosthodontically treated with CAD/CAM-manufactured all-ceramic restorations. To reduce treatment risk, preparations were limited paragingivally. Maxillary anterior teeth and premolars were restored with adhesively luted ceramic crowns. All other teeth were treated with zirconiabased restorations luted with a self-etching resin-based material. Considering the deficient pretreatment situation, the use of tooth-colored restoration and luting materials yielded a satisfying functional and good esthetic result. The patient is highly satisfied, even though 3 minor chippings occurred shortly after the completion of treatment. Keywords: CAD/CAM, Cerec 3D inLab, dental anomalies, dentinogenesis imperfecta, esthetics, Vita In-Ceram YZ, Vita Mark II, zirconia