The aim of this study was to determine the efficacy of a bioresorbable collagen membrane (Bio-Gide) in combination with autogenous bone grafts in the treatment of peri-implant dehiscences, fenestrations, or limited vertical defects. Eighteen titanium dental patients were studied. Autogenous bone was used in all cases to fill the defect and maintain the space underneath the barrier. The collagen membrane was trimmed and adapted to cover the defect in a saddle configuration. The membrane absorbed the blood and easily covered and adhered to the underlying bone. It was not stabilized by any retentive means. Sixteen to 32 months postoperatively, the sites were reentered and the amount of bone regenerated was measured. The results showed significant bone gain (average 87.6%)in the treatment of peri-implant defects with Bio-Gide and autogenous bone.