PubMed ID (PMID): 17622008Pages 417-422, Language: EnglishYou, Tae-Min / Choi, Byung-Ho / Zhu, Shi-Jiang / Jung, Jae-Hyung / Lee, Seoung-Ho / Huh, Jin-Young / Lee, Hyun-Jung / Li, JingxuPurpose: The aim of this study was to compare the effects of platelet-enriched fibrin glue and platelet-rich plasma (PRP) on the repair of bone defects adjacent to titanium dental implants.
Materials and Methods: In 6 mongrel dogs, 3 screw-shaped titanium dental implants per dog were placed into the osteotomy sites in the tibia. Before implantation, a standardized gap (2.0 mm) was created between the implant surface and the surrounding bone walls. Six gaps were left empty (control group), 6 gaps were filled with autogenous particulate bone mixed with PRP (PRP group), and 6 gaps were filled with autogenous particulate bone mixed with platelet-enriched fibrin glue (fibrin glue group).
Results: After 6 weeks, the bone-implant contact was 59.7% in the fibrin glue group, 29.2% in the PRP group, and 10.2% in the control defects; this difference was statistically significant (P .05).
Discussion and Conclusion: Greater bone-implant contact was achieved with platelet-enriched fibrin glue than with PRP. The results indicate that platelet-enriched fibrin glue can induce a stronger peri-implant bone reaction than PRP in the treatment of bone defects adjacent to titanium dental implants.
Keywords: bone grafting, bone regeneration, dental implants, fibrin glue, platelet-rich plasma