Purpose: The purpose of this in vitro study was to investigate the effect of impression technique and implant angulation on the impression accuracy of external- and internal-connection implants using a novel experimental device. Materials and Methods: An experimental device was designed and fabricated to make in vitro impressions by means of open- and closed-tray techniques. Impressions of eight implants with two different connections (four external-hex and four internal-hex) at three angulations (0, 15, and 25 degrees) were made using a medium-consistency polyether material. Evaluation of implant impression accuracy was carried out by directly measuring the difference in coordinate values between the implant body/impression coping positioned on the base and the impression coping/laboratory analog positioned in the impression using a touch-probe coordinate measuring machine. Experimental data were analyzed by two-way analysis of variance. The significance level of all hypothesis testing procedures was set at P .05. Results: The results showed that: (1) for implants with external connections, impression accuracy is not significantly affected by the impression technique, implant angulation, or their interaction; and (2) for implants with internal connections, impression accuracy is significantly affected only by implant angulation: Impression inaccuracy was greater at the 25-degree implant angulation. Conclusions: Within the limitations of this in vitro study, the open- and closed-tray techniques had no effect on the accuracy of multiple implant impressions. The interaction between impression technique and implant angulation was also not significant. However, implant angulation significantly affected the impression accuracy when implants with internal connections were used. Keywords: external-connection implants, implant angulation, impression accuracy, impressions, internalconnection implants