Purpose: To review a series of 454 pterygoid implants placed more vertically than the previous standard angle (45 degrees) over a functional loading period ranging from 2 months to 14 years with a mean follow-up period of 6 years. Materials and Methods: A retrospective study was made. The sample was composed of patients rehabilitated with pterygoid implants between January 1997 and December 2010. Patient selection criteria included: edentulism on the posterior area of an atrophic maxilla, with less than 8 mm remaining from the sinus floor to the alveolar crest, and the presence of an anterior implant or tooth to ensure mesial support for a partial denture. After a healing period between 2 and 7 months, panoramic x-rays were taken at the time of loading. The implant length, implant diameter, implant success, and the angulation of the pterygoid implants were measured. Results: Three hundred ninety-two patients (206 women and 186 men) ranging in age from 34 to 75 years were fitted with 454 pterygoid implants and followed up. The 18-mm implant length was the most favored implant to fit in the pterygoid area. Implant diameter was 3.75 mm in 448 cases (98.6%). The mean mesiodistal angulation of the pterygoid implants was 70.4 degrees ± 7.2. After a mean follow-up period of 6 years, 96.5% of the implants placed were successfully osseointegrated. Conclusions: The findings indicate that a mesiodistal inclination of the pterygoid implant at 70 degrees relative to the Frankfort plane following the bony column of the pterygoid region decreases the non-axial loads of the rehabilitations and exhibits good long-term survival; however, further studies are needed to assess the long-term survival of implants in the pterygomaxillary region. Keywords: atrophic maxilla, follow-up period, pterygoid buttress, pterygoid implant