Purpose: The use of a magnesium-based bone cement, OsteoCrete, has shown promise as a means to secure bone and tendon-to-bone connections in orthopedic medicine. The presence of a bone cement to fill the residual socket and stabilize a dental implant during healing could make immediate implant placement in molar sites more predictable. The aim of this study was to determine whether this magnesium-based bone cement can be used predictably for this purpose. Materials and Methods: The mandibular third premolars and first molars were extracted bilaterally from four mongrel dogs (60 to 80 lb each). Implants were placed in each extraction socket and supported by only 2 to 3 mm of apical furcation bone. OsteoCrete bone cement was placed randomly for implant stabilization in half of the sites. Clinical healing was evaluated until the 4-month time point. All animals were then sacrificed, and mandibular en bloc resection was performed for histologic evaluation of the biologic response and bone-to-implant contact. Results: Clinically, healing showed a poor response when the test site implant was left exposed in a one-stage manner. No statistically significant difference was noted in bone-to-implant contact (52% in test sites versus 44% in control sites). Histologic specimens showed no adverse biologic response to the material but only minimal replacement at 4 months. Conclusions: OsteoCrete bone cement was successful in stabilizing the immediate dental implant in a large extraction socket when placed in a closed environment in the dog model but did not show a benefit as compared to controls. The limited data warrant further studies to determine the further potential of this material.