Objective: The purpose of this study was to evaluate the oral health-related quality of life and pain in patients with acceleration devices during orthodontic treatment with Invisalign. Methods: Thirty patients were randomly assigned to three groups: control group (without additional accelerating devices, changing aligners every 7 days); Acceledent group (with Acceledent accelerating device aligners, changing every 6 days); Orthopulse group (with Orthopulse accelerating device aligners, changing every 6 days). The Oral Health Impact Profile (OHIP) questionnaire was used after the orthodontic treatment to measure the OHIP. This was a modified self-administered short version of the German Oral Health Impact Profile (OHIP-G16) questionnaire. Results: Due to the reduced number of patients included in the study, as well as the individual differences in the groups, no sufficient statistical data could be obtained, but only trends stated. One trend seemed to be reduced pain both at the beginning of a new pair of aligners and during the orthodontic treatment in the Acceledent group and the Orthopulse group. Conclusion: The accelerated orthodontic treatment using the Invisalign system, with the help of vibrating or low-level light emitting devices, may reduce pain. Keywords: acceleration devices, aligner, oral health-related photobiomodulation, quality of life and pain, vibration therapy