Objective: The aim of this study was to evaluate the influence of Carisolv on the shear bond strength (SBS) of hydrophilic adhesive systems in dentin. Method and materials: Two hundred bovine incisors were polished with 320- to 1,000-grit aluminum oxide paper and randomly divided into 10 groups (n = 20). The adhesive systems were used according to manufacturer's instructions, and a restorative resin composite (Definite) was inserted in a Teflon matrix and cured. The specimens were kept in humid storage for 7 days at 37°C. The SBS tests were performed in an EMIC universal testing machine with a crosshead speed at 0.5 mm/min. The mean values (MPa ± [SD]) were analyzed with analysis of variance and Dunnett and Tukey tests. Results: The results were expressed in decreasing values (MPa): G6 = 18.55 ± 6.95; G3 = 17.55 ± 5.73; G2 = 17.05 ± 5.33; G8 = 16.95 ± 7.13; G7 = 16.94 ± 5.22; G4 = 16.31 ± 3.38; G1 = 15.85 ± 4.45; G9 = 14.21 ± 5.87; G5 = 12.89 ± 3.79; and G10 = 12.31 ± 5.18. Conclusion: Carisolv did not interfere in the adhesion to dentin, but its cleanser technique did interfere.