An experimental animal model is presented for the analysis of the influence of axial and nonaxial loading on bone remodeling around oral implants. Axial and nonaxial loading conditions were introduced by placing a bilaterally supported fixed partial prosthesis and a cativlever fixed partial prosthesis on two IMZ implants in the mandibles of beagle dogs. Quantitative and qualitative histologic analyses revealed different remodeling tendencies between the loading conditions. Axial loading induced a more uniform, histologically quiescent remodeling response that gradually deveased from the coronal aspect to the apex of the implant. Nonaxial loading elicited a more dynamic remodeling of the surrounding cortical and especially trabecular bone tissue.