Tardive dyskinesia (TD) is an involuntary movement disorder of neurologic origin caused by the use of neuroleptic drugs known as dopamine receptor antagonists. The condition may adversely affect prosthodontic interventions and their possible merits. In this case history description, the rigor of scrupulous history-taking and clinical evaluation of patients with TD or neurologic disorders is emphasized. The successful prosthodontic management of a 74-year-old completely edentulous TD patient is presented, with the conclusion that a prosthodontic intervention may aid symptom reduction and contribute to improvement in a TD patient's quality of life.