Regenerative periodontal surgery is an effective procedure for the treatment of intrabony defects.Various flap designs that preserve defect-associated interdental papillae have been proposed toimprove early wound stability. This case report describes the long-term results of a regenerativetreatment in a severely compromised mandibular canine using the entire papilla preservation technique. Surgical access was provided by a single buccal vertical incision without any papilla incision.A combination of autogenous bone harvested from the same surgical site and recombinant humanfibroblast growth factor-2 was applied to a noncontained intrabony defect following the removalof granulation tissue. The surgical site was closed with single interrupted sutures. The clinical outcomes after 5 years showed stable pocket closure without any increase in gingival recession, highlighting the potential of the entire papilla preservation technique with the use of combined biomaterials.