Background: The use of ceramic-coated patient-specific CAD/CAM titanium abutments

represents a therapeutic option for the rehabilitation of single tooth. The utilization of highly

customized abutments enables the accurate three-dimensional positioning of the prosthetic

emergence. This study evaluates the clinical performance of implant-prosthetic rehabilitations

carried out using ceramic-coated CAD/CAM titanium abutments. Materials and methods: Thirty

implants were placed in thirty patients and rehabilitated with thirty single crowns attached to

CAD/CAM titanium abutments. A conventional procedure was applied, with implant placement

after post-extraction socket healing and prosthetic restoration after implant healing. Implants of

lengths ranging from 6-15 mm and widths of 3.6, 4.2, and 4.8 mm were used in this study. At the

time of prosthesis delivery (T0), after two years (T1), and after five years (T2), plaque (PI) and

bleeding (BoP) indices, probing depths (PPD), marginal bone levels (MBL), and PES/WES were

evaluated for each implant. Results: No patient dropped out of the study during the follow-up

period. All thirty implants were clinically successful at five years post-prosthesis delivery

(survival rate: 100%) and showed no signs of peri-implant infection. Peri-implant soft tissues

were in good health (BoP at T2: 0% in 73% of patients; 25% in 13% of patients; 50% in 10% of

patients; and 75% in 3% of patients). The mean PPD was 2.05±0.56 mm at T0, 1.992±0.6 mm at

T1, and 1.867±0.439 mm at T2. The mean MBL at T0 was 0.413±0.440 mm, at T1 was

0.306±0.388 mm, and at T2 was 0.263±0.368 mm. The mean PES, WES, and PES/WES indices,

7.43±1.04, 7.57±0.82, and 15.00±1.17, respectively, indicate good integration of soft tissues,

satisfactory aesthetics, and an overall positive outcome. Conclusions: The success rates,

maintenance of marginal bone levels, and periodontal and aesthetic indices suggest the validity

of implant-prosthetic rehabilitations with CAD/CAM abutments in cases of single crowns.