Purpose: Sintering procedures influence the properties of zirconia. This study evaluated the effect of varying sintering rates on flexural strength (σ) of 3, 4, and 5 mol% yttria (Y) containing monochrome (Mo) and multilayer (Mu) zirconia. Materials and Methods: 270 specimens (width×length×thickness = 11.2×20×1.5 mm) were prepared from Mo and Mu of 3Y, 4Y, and 5Y zirconia and randomly sintered at regular (RS: 10 °C/min), fast (FS: 35 °C/min), and speed (SS: 70 °C/min) sintering (n = 15/group). Three-point bending test was determined for σ. ANOVA and Bonferroni test were analyzed for significant differences of σ (a=0.05). The microstructure and crystalline [monoclinic (m), tetragonal (t), and cubic (c)] phases were evaluated by SEM and XRD.Results: σ of zirconia was affected by zirconia type, shade pattern, and sintering rate. Significant higher σ for 3Y>4Y>5Y (p<0.05). Significant greater σ for Mu>Mo (p<0.05). Significant reduction of σ upon SS than RS and FS (p<0.05). However, no significant effect on σ upon varying sintering rates within each type of zirconia (p>0.05). SEM indicated greater grain size in 5Y than in 4Y and 3Y. XRD indicated higher t phase in 3Y, whereas higher c phase in 5Y. Mo indicated a higher c phase than Mu.Conclusions: σ was influenced by Y content (3Y>4Y>5Y), shade pattern (Mu>Mo), and sintering rate (RS@FS>SS). Nonetheless, no influence of varying sintering rates on σ for each type of zirconia, suggesting sintering zirconia with RS and FS for expecting higher σ and at SS for acceptable σ for chair-side cost-effective restoration.