Modern all-ceramic systems offer a highly esthetic, biocompatible, and functional alternative to traditional restorative materials. Such systems allow for a wide range of indications, from inlays to multiple-unit fixed partial dentures, and are increasingly used in posterior regions of the mouth. Many of these systems have been introduced to the market only recently. However, new materials and techniques should be followed up and their clinical performance proven for at least 5 years before they become routine modalities of treatment. This article reviews the current literature and scientific data on the long-term success of all-ceramic restorations in the posterior region and compares and discusses alternative treatment options.