Objective: The objective was to examine the association between health attitudes and behaviors, and oral health practices in Israel. Method and Materials: Secondary data analysis was performed of a cross-sectional national Knowledge, Attitudes and Practices (KAP) survey in Israel. Univariate and multivariate analysis assessed the association between health attitudes and behaviors and oral health practices, namely tooth brushing frequency and routine dental clinic attendance. Results: A statistically significant association was found between gender (women), ethnicity (Jews), socioeconomic status (higher), education (higher), and employment (yes), and better oral health practices. A statistically significant association was also observed between clustered health-compromising behaviors (HCB) and oral health practices: the higher the score, the higher the likelihood of inappropriate tooth brushing and dental clinic attendance (OR = 1.56, 95% CI = 1.85-2.62, and OR = 2.20, 95% CI =1.31-1.86, respectively). A significant association was also observed using a compound variable of negative health attitudes (NHA): the higher the score, the higher the likelihood of inappropriate tooth brushing and dental clinic attendance (OR = 1.43, 95%CI = 1.55-2.17, and OR = 1.84, 95% CI = 1.22-1.68, respectively). Conclusion: Positive general health behaviors and attitudes are associated with better oral health behaviors in a dose-response association. These findings should be used to design appropriate and tailored health promotion programs in order to achieve oral and general behavioral change. Interventions should be also targeted toward high-risk groups in the population. Keywords: health attitudes, health behaviors, Israel, oral health behaviors, sociodemographic variables