Purpose: The aim of this study was to evaluate the long-term clinical performance of and patient satisfaction with implant-supported all-ceramic fixed dental prostheses (FDPs) and to compare two different all-ceramic systems, Denzir (DZ) and In-Ceram Zirconia (InZ). Materials and Methods: A total of 18 patients received 25 partial FDPs; 13 DZ, and 12 InZ. Results: Of these patients, 17 attended the 10-year follow-up. None of the restorations had fractured. Fractures of the veneering porcelain were observed in nine patients; two from the InZ group and seven from the DZ group. All FDPs were in use, and all patients were fully satisfied with the treatment. Conclusion: Results from this long-term follow-up suggest that implant-supported all-ceramic FDPs are an acceptable treatment alternative.