Epidermolysis bullosa belongs to a group of genetic diseases that present with skin disorders and is characterized by generalized blister formation in response to mechanical trauma. This article reports on the management of a recessive dystrophic epidermolytic patient with four remaining periodontally compromised maxillary teeth. Treatment involved placement of four maxillary implants and use of computer-aided design/computerassisted manufacture techniques to fabricate a fixed full-arch implant-supported prosthesis. The prescribed dental treatment protocol led to a successful short-term prosthodontic outcome.