Aims: To determine the prevalence of facial pain and temporomandibular disorders (TMD) in people located in urban and rural areas in a newly industrialized country (Iran). Methods: Two-hundred twenty-three subjects between 18 and 65 years of age (mean: 32.07; SD: 10.83) were randomly selected from an urban area and a rural area. One-hundred nineteen subjects from Mashhad (major city) and 104 subjects from Zoshk (village) were voluntarily recruited from medical health-care centers. Subjects who consulted the health-care center for dental, ear, nose, or throat issues were excluded. The monitoring of public health attendance of all citizens at designated health-care centers is compulsory by local law. All subjects were examined in accordance with the Research Diagnostic Criteria for TMD (RDC/TMD). Facial pain was assessed by using a questionnaire; the prevalence of myofascial pain, disc displacement, and degenerative disorders was determined by clinical examination. Nonparametric tests were used to assess group differences (ie, between village and city). Results: Subjects in urban areas suffered less from facial pain (20.2% versus 46.2%; P .01 [Mann-Whitney U test]) than subjects in rural areas. The frequency of TMD, disc displacement, and degenerative disorders was greater in the rural area. Conclusion: The symptoms under investigation were significantly more widespread in rural than in urban areas. With regard to TMD per se, the place of residence appears to be unimportant. However, the rural population was significantly affected by facial pain. Keywords: degenerative disorders, disc displacement, facial pain, myofascial pain, prevalence