The present article introduces preliminary clinical and histologic evidence on the combination of a platelet-rich plasma and anorganic bovine bone in maxillary sinus augmentation procedures. The clinical and histologic results from 10 patients underline the different clinical and biologic advantages offered by the combined use of a well-known osteoconductive material, anorganic bovine bone, and a new technique that consists of stimulating bone regeneration using the local increase of growth factors contained in autologous platelet-rich plasma.