This study looked at a bone-substitute biomaterial (Biostite) used to fill bone defects around immediate implants in humans. Ninety-six peri-implant bone defects were treated without the use of membranes, comparing two groups: group A = filling the defect with Biostite, and group B = no defect fill. After 4 to 6 months of healing, group A revealed higher percentages of implants covered by new, bone-like tissue (67% in group A, 34% in group B). Endochondral osteogenesis was demonstrated histologically in the regenerated tissues in alveolar sites treated, allowing the hypothesis of bone induction from the filling material used.