The application of immediate loading of implants in the edentulous maxilla in multiple-risk patients is presented. Five partially edentulous patients attended with failing prostheses supported by hopeless teeth. An immediate-loading protocol was proposed because the patients rejected provisionalization with a removable prosthesis. Multiple teeth were extracted, and 44 immediately loaded implants were placed, most of them (55.5% to 88.9%) in fresh extraction sites, to support a cross-arch prosthesis that was loaded 3 to 4 days after surgery. The overall implant failure rate was 13.4%; in healed sites it was 20% (2/10) and in fresh extraction sites it was 8.82% (3/34). Prosthetic success was 100%. The overall failure rate was higher than is usually seen with the standard delayed-loading approach. Nevertheless, this immediate-loading protocol was satisfactory for the patients and the practitioner because prosthetic success was maintained during the provisionalization phase.