DOI: 10.11607/prd.3778, PubMed ID (PMID): 30304068Pages 791-798, Language: EnglishSalama, Maurice A. / Pozzi, Alessandro / Clark, Wendy Auclair / Tadros, Marko / Hansson, Lars / Adar, PinhasInadequate restorative space can result in mechanical, biologic, and esthetic complications with full-arch fixed implant-supported prosthetics. As such, clinicians often reduce bone to create clearance. The aim of this paper was to present a protocol using stacking computer-aided design/computerassisted manufacturing (CAD/CAM) guides to minimize and accurately obtain the desired bone reduction, immediately place prosthetically guided implants, and load a provisional that replicates predetermined tissue contour. This protocol can help clinicians minimize bone reduction and place the implants in an ideal position that allows them to emerge from the soft tissue interface with a natural, pink-free zirconia fixed dental prostheses.