Chronic periodontitis progression may go through phases of remission and exacerbation. The possibility of periodontal pathogens translocating from infected periodontal sites to peri-implant sites has been reported. Additionally, a history of periodontal disease seems to be a risk factor for peri-implantitis. The present case reports a flare-up of chronic periodontitis concomitant with an episode of peri-implant infection on a documented stable implant site. Periodontal infection was managed nonsurgically by scaling root planing and antibiotic treatment. Peri-implant infection was treated by open-flap debridement and implant surface decontamination. A remarkable regeneration on the peri-implant defect occurred steadily over a 3-year period, leading to a full regeneration of the site relying exclusively on the individual healing resources.