Introduction: Nano desensitizers were recently introduced, specifically nano-hydroxyapatite, the nanometric proportions of n-HA allows an easier obliteration of dentinary tubules. Methods: The database of this research on pubmed central and pubmed/medline was conducted according to the keywords: dentin hypersensitivity, dentin sensitivity, n-HA, nano-HA, nano hydroxyapatite, combined with the connectors "AND" and "OR" (dentin hypersensitivity OR dentin sensitivity) AND (n-HA OR nano-HA OR nano hydroxyapatite). Results: From a universe of 208 studies, 5 were included. Conclusions: In this systematic review, all the included studies have shown the effectiveness of nano-hydroxyapatite by reducing dentin hypersensitivity in a minimal period of four weeks. Keywords: dentin hypersensitivity, nano-Hydroxyapatite, desensitizers