Purpose: To identify and measure distortions inherent in the casting process of a Class III mandibular cobalt-chromium (Co-Cr) framework to illustrate the problems faced by the laboratory technician and the clinician and to measure the changes that occur during the correction of the fit discrepancy using laser welding. Materials and Methods: Five identical castings of a Co-Cr alloy partial denture casting were made and measured between 3 widely separated points using the x, y, and z adjustments of a Nikon Measurescope. The same measurements were made after each of the following clinical and laboratory procedures: sprue removal, sectioning of the casting into 3 parts through the posterior meshwork, fitting the segments to the master cast, picking up the segments using resin, and laser welding of the 3 segments. Results: Measurements of all 5 castings showed a cross-arch decrease after sprue removal, an increase after fitting the segments to the master cast, and a slight decrease after resin pickup and laser welding. Conclusions: Within the limitations of this study, the findings suggest that precise tooth-frame relations can be established by resin pickup and laser welding of segments of Co-Cr removable partial denture frameworks.