The mouth is the mirror of body in health or in disease. It acts as a sentinel or early warning system. Many times, manifestation in the jaw can be an early indicator of systemic diseases such as haematological, metabolic, and endocrinal disorders. Hyperparathyroidism (HPT) is the excessive production of parathyroid hormone by parathyroid glands. HPT can be primary, secondary, or tertiary. Radiographically, loss of lamina dura and altered trabecular pattern can be the early manifestations of HPT on the jaw. We present a case of 36-year-old female who reported with pain in jaw for 1 year. The case was provisionally diagnosed solely on the basis of panoramic radiograph and confirmed further as primary hyperparathyroidism due to right inferior parathyroid adenoma with advanced radiographic and laboratory findings.