Amine fluoride, the active ingredient of a currently marketed dentifrice in Germany and other European countries, and sodium fluoride were compared to a placebo dentifrice for their effectiveness in alleviating dentinal hypersensivitiy. This was a randomized, double-blind, two-center, parallel clinical study covering 8 weeks of product use by 115 subjects. The hypersensitivity of the affected teeth was assessed by tactile stimulation, cold air stimulation, and overall subjective patient response. The three treatment groups exhibited comparable baseline sensitivity. These three methods of clinical assessment demonstrated that the desensitizing ability of a relatively higher fluoride dentifrice (1,400 ppm), delivered either as amine fluoride or sodium fluoride, did not differ significantly from that of the placebo dentifrice