Purpose: The aim of this in vitro study was to assess the resistance to static fatigue of implants with different connections before and after implantoplasty. Materials and Methods: Sixty conical implants and 60 abutments were used; 4-mm-diameter versions were available for each model. Three groups (n = 20) were established based on the following implant connections: external hexagon (group 1), internal hexagon (group 2), and Morse taper (group 3). The implants of each group were submitted to a compressive load before (n = 10) and after the implantoplasty (n = 10). The wear was performed in a mechanical lathe machine using a carbide bur, and the final dimensions of each sample were measured. All groups were subjected to quasi-static loading at a 30-degree angle to the implant axis in a universal testing machine and 5 mm out of the implant support. Results: After the implantoplasty, the mean final diameter was 3.13 ± 0.033 mm for group 1, 3.23 ± 0.023 mm for group 2, and 3.25 ± 0.03 mm for group 3. The mean fracture strengths for the groups before and after the implantoplasty were, respectively, 773.1 ± 13.16 N and 487.1 ± 93.72 N in group 1; 829.4 ± 14.12 N and 495.7 ± 85.24 N in group 2; and 898.1 ± 19.25 N and 717.6 ± 77.25 N in group 3. Conclusion: Resistance to loading decreased significantly after implantoplasty, and varied among the three implant connection designs. Keywords: dental implant, fracture mode, fracture strength, implant connection, implantoplasty