Adhesion failure of resilient lining materials to poly(methyl methacrylate) denture base material is a problem that is encountered clinically. This study compared the shear bond strength of some of the commercially available resilient lining materials to various denture base resins. Significant differences were observed in the shear strengths between the selected resilient liners and the denture base materials. Coe Super Soft specimens failed principally cohesively. Molloplast-B specimens always failed cohesively and Novus specimens always failed adhesively. Therefore, it was apparent that the bond strengths of Molloplast-B and Coe Super Soft specimens exceeded the cohesive strength. The bond strength of Novus was dependent on the denture base material and was greatest with Lucitone 199 and TS 1195.