This study compared the fracture load and failure types of implant-supported zirconia all-ceramic crowns cemented with various luting agents. The ceramic frameworks were fabricated from a presintered yttria-stabilized zirconium dioxide block using computer-aided design/computer-assisted manufacturing technology, and were then veneered with feldspathic porcelain. Three luting agents were used. Composite resin cement (1,560.78 ± 39.43 N) showed the highest mean fracture load, followed by acrylic/urethane cement (1,116.20 ± 77.32 N) and zinc oxide eugenol cement (741.21 ± 41.95 N) (P .05). The types of failure varied between groups.