Treatment of patients with microstomia due to scleroderma is complicated. Limited mouth opening and altered finger shape present difficulties at every step of the prosthetic rehabilitation. This article describes the prosthetic management of an edentulous patient with severe microstomia induced by scleroderma. From among the existing treatment options and according to the patient's ability and financial considerations, the authors provided a simple prosthetic design that effectively facilitated the patient's rehabilitation. To plan treatment for a patient with scleroderma, it is important to have knowledge about existing complications, alternative methods, and the patient's ability and comfort. Int J Prosthodont 2014;27:169-173. doi: 10.11607/ijp.3550