Bilateral or unilateral congenitally missing maxillary lateral incisors is a common clinical situation that requires an interdisciplinary approach. It is often complicated by the presence of narrower teeth. Occlusal, periodontal, and esthetic considerations will influence the decision to close the space for a canine-lateral substitution or to open the space for a prosthodontic replacement of the missing lateral incisor. The team should define the proper dental position to provide a stable occlusion and dental esthetics obtained with a minimally invasive preparation. The restorative approach should provide a long-term functional and esthetic solution in the transitional period from adolescence to adulthood, reversible for future possible interventions. Keywords: dental position vs dental form, space closure vs space opening, hypodontia with smaller teeth, implant or one-wing fixed dental prosthesis (FDP)