Full mouth rehabilitation with immediate loading implants has become a predictable procedure whereas implant and prosthesis survival are concerned. However less information is known from the patient centered outcomes measures perspective. This was a practice based prospective single cohort study aiming at studying the Impact of immediate loading implant supported full mouth rehabilitation on the oral health related quality of life (OHRQoL). 43 patients were recruited in a Portuguese dental clinic. Inclusion criteria were indication of full mouth rehabilitation with immediate loading protocol, exclusion criteria were nonnative Portuguese language. A Portuguese version of the Oral Health Impact Profile 14 was administered at study baseline before the intervention (visit 1), day 10 (visit2), 1 month (visit 3) and 6 months follow up (visit 4). Predictive variables were age, gender, household owning, marital status, education, profession, dental needs, type of rehabilitation provided and visit number. Primary outcome was total OHIP 14 PT score and partial domains. Glass effect size was calculated. Mean differences were tested with paired student t test and significance was set at alpha 5 %. Total OHIP 14 scores at visits 1, 2, 3 and 4 were 18,00±11,20 SD; 11,47±7,95 SD; 5,84±4,07 SD; 5,02±3,04 respectively. There was an extremely significant improvement in OHRQoL along the study follow up (p<0,001 Paired Student t Test) except for comparisons between visit 3 and 4 for every OHIP 14 domain. Full mouth rehabilitation with immediate loading protocol significantly increases the OHRQoL, from baseline through six months follow up.