Treatment of acute cases of amelogenesis imperfecta (AI) is challenging in children due to the absence of a consensus statement on therapeutic recommendations. This article presents the effectiveness of an interdisciplinary approach—including orthodontics, orthognathic surgery, and prosthodontics using digital technology—in a child with AI and skeletal deformities. The early management over a 6-year period had a very positive impact on the quality of life related to oral health. The full-mouth rehabilitation in adulthood with all-ceramic crowns showed a fully satisfactory result after 60 months of follow-up.