Purpose: To clarify the influence of clenching strength on interocclusal registration using an intraoral scanner (IOS). Materials and Methods: The study includes eight volunteers as subjects, and the two experimental conditions were light clenching (LC) and 40% maximum voluntary clenching (MVC). Conventional silicone bite registration and an IOS were used for comparison. Occlusal contact areas (OCAs) for different clenching strengths were compared, along with variation of measured values (VMVs) between recording methods. Results: Significant differences were observed between conditions on OCA and between methods on VMV. Conclusions: Clenching strength influenced interocclusal registration using IOS.