Purpose: To analyze the marginal adaptation of computer-aided design/computer-assisted manufactured (CAD/CAM) porcelain laminate veneers. Materials and Methods: A total of 25 three-dimensional (3D) machine-milled laminate veneers were divided into five groups of five each according to fabrication material (E-max; Empress; Lava Ultimate; Suprinity; and Vita Mark II) and cemented in 25 prepared acrylic central incisors. Digital microscopy images (×7.5 magnification) were analyzed for gaps in the mesial/distal surfaces of the prepared tooth and in the cervical, medial, and incisal thirds. Results and Conclusion: All CAD/CAM laminate veneers except for Empress and Suprinity in the middle and incisal thirds showed good results (ie, gaps 120 μm in the cervical, middle, and incisal thirds).