Purpose: To quantify the strain development of a new prefabricated implant-supported mandibular full-arch reconstruction. Materials and Methods: Five resin models reflecting edentulous mandibles were each restored with three interforaminal implants and prefabricated frameworks with a novel compensation mechanism, cast frameworks, and computer-aided design/computer-assisted manufacturing (CAD/CAM)-fabricated frameworks. Strains were recorded during superstructure fixation. Statistical analyses (analysis of variance, t tests; α = .05) were based on level of misfit and distribution of misfit. Results: Cast restorations showed significantly higher levels of misfit and a significantly more uneven distribution of misfit compared to prefabricated and CAD/CAM restorations (P .05 for all comparisons). Prefabricated and CAD/CAM frameworks showed a similar low level and distribution of misfit (P = .24145 and P = .2837, respectively). Conclusion: The compensation mechanism of the prefabricated frameworks provides a level of fit comparable to CAD/CAM superstructures.