Purpose: To clinically evaluate the use of ceria-stabilized zirconia/alumina nanocomposite (Ce-TZP/A) for the frameworks of removable dental prostheses (RDPs). Materials and Methods: A total of 20 Ce-TZP/A RDPs (10 complete dentures and 10 implant-supported overdentures) were used in 16 patients, and the presence/ absence of complications and patient complaints were evaluated. Results: The survival rate of the RDPs during a mean follow-up period of 55.6 months was 100%, with no major complications. Conclusion: The patients experienced uneventful courses functionally and esthetically. In addition, there was no incidence of breakage or repair related to the Ce-TZP/A frameworks.