Guided tissue regeneration, the principle of using membranes to exclude epithelial tissue during wound healing, thus enhancing periodontal regeneration, is an exciting addition to the implant armamentarium. However, additional clinical review of the results, advantages, and disadvantages of guided tissue regeneration is necessary before the procedure can be recommended for routine use. To this end, the author reports three representative cases in which membranes were used to encourage healing and discusses the results and problems.