Achieving functional and esthetic implant-supported single-tooth restorations in the anterior region of the maxilla can be particularly challenging. Insufficient hard tissue can preclude proper implant positioning, while inadequately treated soft tissue will not exhibit a gingival appearance similar to that of the adjacent teeth. The aims of this article are to analyze the different clinical possibilities (standard and compromised situations) for implant-supported single-tooth restorations in the anterior zone and highlight the importance of knowing the biologic, anatomic, surgical, and prosthetic concepts, particularly the interproximal bone height of adjacent teeth, in the prognosis and predictability of achieving an esthetic result.