The fifth edition of this popular textbook includes a new clinical section and additional illustrations. The authors create a refreshing self-study approach using direct langua and helpful metaphors. Self tests are strategically placed f the board examinations, or as a refresher for busy practitioners who want to stay abreast of this rapidly advancing field. Clearly written, with numerous illustration and tables.
Contents
Part I: Acute Inflammatory Process
- Preface
- Introduction
- Abbreviations
- Vascular Response to Injury
- Quick Review
- The vascular events
- Exudation, transudation, and edema
- The lymphatic system
- Postscript
Chemical Mediators of the Vascular Response
- Histamine
- Serotonin
- Plasma proteases
- The kinin system
- The fibrinolytic system
- Advice from some old friends
- The complement system
- Eicosanoids
- Platelet activating factor
- Nitric oxide
- Neuropeptides
- Other mediators
- Pain associated with acute inflammation
The Blood Leukocytes
- The cells involved
- The individual leukocytes
- The mononuclear-phagocytic system
Systemic Manifestations of Inflammation
Part II: Immunity
The Immune System
- The opponents
- The defenders
- Antigen-presenting cells
- The system
- Immunoglobulins
- General battle plan
- Duration of antibody response
Hypersensitivity Reactions
- Type I - immediate-type hypersensitivity
- Type II - Immune cytotoxic reactions
- Type III - Immune complex hypersensitivity
- Type IV - Delayed-type hypersensitivity
- Immunologic tolerance
- Immunodeficiency
Chronic Inflammatory Processes
- General considerations
- Causes of chronic inflammation
- Factors contributing to chronicity
- Maintenance of chronicity
- Other cells involved
- Tissue damage
- Chemical mediators
- Essential elements
- Granulomatous inflammation
- Control of inflammation
Part III: Repair of Host Tissues
Healing
- Resolution vs repair
- Regeneration
- Fibrous repair
- Cell-matrix interaction
- Cell-cell interaction
- The role cells play in wound healing
- What is organization?
- Epithelialization
- Strength of healing wounds
- Remodelling of wounds
- Local and systematic factors influencing healing
Part IV: Application of Basic Principles
Clinical Connections
- Inflammation of the tooth pulp (pulpitis)
- Inflammatory lesions of the periapical tissues
- Acute pyogenic osteomyelitis of the jaws
- Chronic osteomyelitis of the jaws
- Cellulitis
- Periodontal disease
- Acquired immunodeficiency syndrome
- Answers to Self-Test and Charts
Index
