Extrusion of separated endodontic instruments is a frustrating complication that can occur during root canal treatment and is difficult to handle. This report aimed to introduce different methods to retrieve such separated instruments through three cases with different locations of fragments. Fragments extruded completely into the maxillary sinus, partially into the maxillary sinus and lying in the soft tissue were retrieved using a lateral window approach, ultrasonic method and minimally invasive surgery, respectively. These methods can be recommended for retrieving fragments in certain cases. Keywords: lateral wall approach, maxillary sinus, separated instrument, soft tissue, ultrasonic technique