Purpose: A 3-dimensional finite element model consisting of a bone block and 2 simulated premolar crowns supported by 2 adjacent cylindric implants without immediately surrounding cortical bone was generated and used to investigate the effects of prosthesis materials and prosthesis splinting on the peri-implant bone stress under static loads. Materials and Methods: The peri-implant maximum equivalent bone stress (von Mises [VM] stress) was evaluated when a vertical or a horizontal load of 1 N was applied to the center of a single resin, gold alloy, or porcelain crown, nonsplinted or splinted to the adjacent crown. Results: The numeric results indicated that: (1) in a single crown, no significant difference could be found in the maximum VM stress between different materials for both vertical and horizontal loading; (2) splinting the crowns reduced the maximum VM stress induced by the horizontal load, and the maximum VM stress increased about 14% for the horizontal loading when the restorative material was changed from gold alloy or porcelain to resin. Discussion: Under the condition of this study's analysis, prosthesis materials of a single crown have insignificant effects on the peri-implant bone stress. Splinting the crowns reduced the peri-implant bone stress under horizontal load, and gold alloy and porcelain each demonstrated less peri-implant bone stress than resin in the splinted crown situation under static horizontal load. Conclusion: Splinting the crowns of adjacent implants with relatively stiff restorative materials is recommended for implants surrounded by poor-quality bone. Keywords: dental implants, finite element analysis, prosthesis material